Are G3 ENETS neuroendocrine neoplasms heterogeneous?
نویسندگان
چکیده
منابع مشابه
Are G3 ENETS neuroendocrine neoplasms heterogeneous?
The new WHO classification of gastroenteropancreatic (GEP) neuroendocrine tumors (NET) implies that G3 neoplasms with mitotic index >20 and/or Ki67 index >20% are neuroendocrine carcinomas (NEC), described as poorly differentiated, small or large cell types, by analogy with lung NEC. To characterize the subgroup of non-small-cell-type GEP and thoracic NET with mitotic index >20 and/or Ki67 >20%...
متن کاملENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms.
a Department of Gastroenterology, Royal Free Hospital, London , and b Department of Radiology, Royal Marsden Hospital, Sutton , UK; c Department of Pathology, Gothenburg University, Gothenburg , Sweden; d PET-Zentrum/ Klinik für Nuklearmedizin, Zentralklinik Bad Berka GmbH, Bad Berka , e Department of Radiology, Campus Virchow-Klinikum, and f Department of Internal Medicine, Charité-Universität...
متن کاملCharacteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms.
Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We retrospectively study patients with NET G3 and NEC from eight European centers. Data examined included clinical and pathological characteristics at diagnosis, therapies and outcomes. Two hundred and four patients were analyzed (...
متن کاملNeuroendocrine tumors: a heterogeneous set of neoplasms.
The review of surgical management of neuroendocrine tumors (NETs) of the gastrointestinal tract, authored by Huang, Poultsides, and Norton, is both comprehensive and accessible for readers of all backgrounds. The authors describe the various tumor types, diagnostic methods, management decisions, and prognoses for a wide array of NETs of the gastrointestinal tract. They highlight the dichotomy b...
متن کاملENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms. Systemic Therapy 2: Chemotherapy.
Systemic chemotherapy is indicated in progressive or bulky advanced pancreatic neuroendocrine tumors (NETs) and in grade 3 (G3) neuroendocrine neoplasms (NENs) as per ENETS Guidelines. Chemotherapy may be considered in NETs of other sites (lung, thymus, stomach, colon, rectum) under certain conditions (e.g., when Ki-67 is at a high level (upper G2 range), in rapidly progressive disease and/or a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2013
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-13-0027